Pfenex Inc.
  • 18-Nov-2019 (PST)
  • San Diego, CA, USA
  • Full Time

Pfenex is a clinical-stage development and licensing biotechnology company focused on leveraging its Pfenex Expression Technology to improve protein therapies for unmet patient needs. Using the patented Pfenex Expression Technology platform, the Company has created an advanced pipeline of therapeutic equivalents, vaccines, biologics and biosimilars.


Pfenex is a clinical-stage biotechnology company engaged in the development of protein therapeutics for unmet patient needs. We are committed to providing innovative solutions for global health. Our team is made up of driven, talented, motivated individuals making an immediate impact within our fast-paced dynamic organization. As a member of the Strain Engineering team, the Strain Engineering Sr. Scientist will contribute to the continued development of the Pfenex Expression Technology platform. The successful candidate will oversee and participate in projects focused on the design, screening, and characterization of recombinant P. fluorescens protein production strains as part of a cross-functional product development team. The ability to work in a matrixed environment and drive innovations are key position attributes.


  • Serves as Strain Engineering/ Molecular Biology subject matter expert in the development and commercialization of biopharmaceutical products across several programs
  • Provides direct technical support to CMC data package for regulatory submission(s) as well as BLA, NDA, and/or IND regulatory review meetings
  • Keeps informed of latest advancements in molecular biology and related technologies, taking initiative to evaluate and present a case for acquisition of appropriate technologies to meet business needs. Influences successful adoption of new technologies across functional areas.
  • Seeks to understand capabilities across disciplines and use innovative, collaborative approaches for solving technical problems.
  • Captures IP through clear documentation of experimental results and assists in the preparation of invention
  • Delivers presentations that distill complex ideas and proactively communicate results and progress to technical
  • Actively creates, generates, and presents papers/presentations at scientific meetings
  • Mentors Scientist and Associate Scientist level employees in problem solving, equipment and process issues
  • Writes technical documents and protocols that describe the production strain and selection process with sufficient detail for successful transfer to CMOs for banking, characterization and manufacturing
  • Ensures laboratory safety practices/goals are followed and achieved


  • BS/MS/PhD in Biology/Microbiology/Biochemistry/Biochemical Engineering or related field
  • BS 8 years of relevant experience w/a minimum of 5 years of industry exp
  • or MS   5 years of relevant experience w/a minimum of 3 years of industry exp
  • or PhD 2 years of relevant industry experience
  • >5 years experience in microbial strain engineering and recombinant protein production
  • Proficient in recombinant DNA technology such as cloning, QPCR, DNA sequencing, and RNA seq
  • Background in current Omics based technologies (e.g. genomics, transcriptomics), bioinformatics tools and statistical analysis are preferred.
  • Positive and enthusiastic team member. Effective planning, communication and problem-solving skills.
  • Good documentation practices are essential
  • Must be proficient in MS Word, Excel, and Powerpoint. JMP or other statistical package
  • Flexible hours essential, be available to troubleshoot equipment and process issues during off-hours.
  • Occasional travel may be needed.

Additional Information 

Affirmative Action and Equal Opportunity Employer (EOE).

Pfenex celebrates the diversity of life and welcomes all individuals to apply.

Must be legally authorized to work in the US without sponsorship

The employee is regularly required to sit, stand, walk; reach with hands and arms, use hands to finger, handle or feel

The employee is required to regularly lift and/or move up to 20 pounds

Specific vision abilities required by this job include close vision, distance vision, color vision, peripheral vision, depth perception and ability to adjust focus

The work environment characteristics described here are representative of those an employee encounters while performing the essential functions of this job.  Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.


Pfenex Inc.
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